Transcutaneous electrical nerve stimulation enhances locomotor adaptation savings in people with multiple sclerosis.

ABSTRACT: Locomotor adaptation on a split-belt treadmill can improve gait symmetry across various clinical populations, including people with multiple sclerosis (PwMS). As many PwMS experience sensory impairments, mobility interventions relying on sensory prediction errors may be less effective. Transcutaneous electrical nerve stimulation (TENS) has been shown to amplify sensorimotor function in PwMS and healthy controls, but its influence on motor learning remains unexplored. This randomized crossover trial investigated the effects of TENS on locomotor adaptation and cortical activation in PwMS. In total, 28 PwMS and 20 age- and sex-matched healthy controls completed two locomotor adaptation sessions, one with active TENS and one with inactive TENS. Locomotor adaptation was evaluated using step len

SUBMITTER: Hagen AC 

PROVIDER: S-EPMC12238753 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature