Dataset Information
DPSCs modulate synovial macrophage polarization and efferocytosis via PINK1/Parkin-dependent mitophagy.
Ontology highlight
ABSTRACT:
SUBMITTER: Ma J
PROVIDER: S-EPMC12239393 | biostudies-literature | 2025 Jul
REPOSITORIES: biostudies-literature
Publications
DPSCs modulate synovial macrophage polarization and efferocytosis via PINK1/Parkin-dependent mitophagy.
Stem cell research & therapy 20250709 1
BACKGROUND: Synovitis is a key factor in temporomandibular joint osteoarthritis (TMJOA) and could be an early sign of the disease. Notably, synovitis and its macrophage component represent a target of interest for developing treatments. Dental pulp stem cells (DPSCs) are derived from the neural crest, coincidentally with maxillofacial tissues, thus attracting significant interest in situ maxillofacial regenerative medicine. However, there is a relative scarcity of studies investigating the role ...[more]