LCZ696 improves oxidative stress injury in human podocytes induced by increased glucose levels via Nrf2/HO-1 signaling pathway.

ABSTRACT:

Background

Uncontrolled diabetes results in diabetic kidney disease (DKD), impacting approximately 40% of individuals with diabetes. Early indicators include podocyte damage and proteinuria, which are influenced by oxidative stress and dysregulation of the Nrf2/HO-1 pathway.

Objective

To examine the potential effect of Sacubitril/valsartan (LCZ696) on the oxidative stress of podocytes induced by hyperglycemia via the signaling pathway.

Methods

Podocytes were categorized into four groups: the first group was exposed to a normal glucose level 5.5 mmol/L, the second group to a high glucose at 40 mmol/L, the third group to a high glucose with LCZ696 at a concentration of 10 µM and the fourth group to a high glucose with Valsartan (VAL) at a concentration of 10 µM. Cell vi

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12239498 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature