Noninferiority Randomized Controlled Clinical Trial Assessing the Antiplaque Efficacy of Fatty Acids-Based Mouthrinse.

ABSTRACT:

Objectives

The market offers many plaque-controlling mouthrinse options, but recent research reveals fatty acids' antimicrobial potential. Despite limited evidence on their antiplaque effects, fatty acids are intriguing for oral care innovation.

Material and methods

This noninferiority randomized clinical trial assessed the antiplaque efficacy of a fatty acids-based (FAG) compared to stannous fluoride (SF) mouthrinse in experimental gingivitis induced by 14 days of oral hygiene cessation. Participants used assigned treatments twice daily for 14 days. Full Mouth Plaque and Bleeding Scores (FMPS/FMBS) served as primary outcomes. Statistical analyses encompassed parametric and nonparametric methods, as well as logistic regression models.

Results

Thirty-one volunteers (22

SUBMITTER: Altamura S 

PROVIDER: S-EPMC12239514 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature