Activation of Sigma 1 Receptor Preserves Visual Function After Optic Nerve Injury.

ABSTRACT:

Purpose

Previous research has indicated that sigma 1 receptor (Sig1R) activation can help retinal ganglion cells (RGCs) survive optic nerve injury. However, in these studies, the treatments were given before the injury. We explored whether activating Sig1R as a post-injury treatment can still preserve visual function.

Methods

Wild-type or Sig1R knockout mice were subjected to optic nerve crush (ONC) injury. The contralateral eye served as sham control. Starting 6 hours after ONC, (+)-pentazocine, or (+)-PTZ, was administered daily. Visual acuity, contrast sensitivity, pattern electroretinography (PERG), visual evoked potential (VEP), and imaging of retinal structure and vasculature were evaluated using OptoMotry, ERG, spectral-domain optical coherence tomography, and fluores

SUBMITTER: Wang J 

PROVIDER: S-EPMC12240203 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature