Mechanically-adaptive, resveratrol-eluting neural probes for improved intracortical recording performance and stability.

ABSTRACT: Intracortical microelectrodes are used for recording activity from individual neurons, providing both a valuable neuroscience tool and an enabling medical technology for individuals with motor disabilities. Standard neural probes carrying the microelectrodes are rigid silicon-based structures that can penetrate the brain parenchyma to interface with the targeted neurons. Unfortunately, within weeks after implantation, neural recording quality from microelectrodes degrades, owing largely to a neuroinflammatory response. Key contributors to the neuroinflammatory response include mechanical mismatch at the device-tissue interface and oxidative stress. We developed a mechanically-adaptive, resveratrol-eluting (MARE) neural probe to mitigate both mechanical mismatch and oxidative stress and the

SUBMITTER: Mueller NN 

PROVIDER: S-EPMC12240817 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature