Cross-tissue multicellular coordination and its rewiring in cancer.

ABSTRACT: The multicellular coordination that underlies tissue homeostasis and disease progression is of fundamental interest^1-5. However, how diverse cell types are organized within tissue niches for cohesive functioning remains largely unknown. Here we systematically characterized cross-tissue coordinated cellular modules in healthy tissues, uncovering their spatiotemporal dynamics and phenotypic associations, and examined their rewiring in cancer. We first compiled a comprehensive single-cell transcriptomic atlas from 35 human tissues, revealing substantial inter-tissue variability in cellular composition. By leveraging covariance in cellular abundance, we identified 12 cellular modules with distinct cellular compositions, tissue prevalences and spatial organizations, and demonstrated

SUBMITTER: Shi Q 

PROVIDER: S-EPMC12240829 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature