Neuroimaging changes in major depression with brief computer-assisted cognitive behavioral therapy compared to waitlist.

ABSTRACT: The goals of the current study were to determine the efficacy in major depressive disorder (MDD) of a shortened, computer-augmented cognitive behavioral therapy (CCBT) protocol and to determine brain plasticity effects following CCBT. Seventy-two MDD participants were randomized to CCBT or waitlist control groups and compared to 40 healthy controls (HCs). Functional MRI data were collected for all participants and repeated for patients following CCBT (five therapist-administered manualized CBT sessions plus computer training exercises). Linear mixed-effects models evaluated changes in depression scores throughout treatment and in connectivity from pre- to post-CCBT. Linear regression models compared connectivity differences between groups (MDD vs. HC). Following CCBT, there were decreases

SUBMITTER: Sheline YI 

PROVIDER: S-EPMC12240849 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature