The impact of body mass index on clinical outcomes in elderly sepsis patients: a retrospective study based on the MIMIC IV database.

ABSTRACT:

Background

Sepsis is a major health threat in the elderly, with high morbidity and mortality. Emerging evidence suggests an "obesity paradox," where higher body mass index (BMI) may improve survival. However, the association between BMI and outcomes in elderly sepsis patients remains unclear.

Methods

Using data from the MIMIC-IV v3.1 database (2008-2022), we conducted a retrospective cohort study of sepsis patients aged ≥ 60 years. After 1:1 propensity score matching based on demographics and severity scores, 9,602 patients (4,801 obese; 4,801 non-obese) were included. Kaplan-Meier curves, Cox regression, and restricted cubic spline (RCS) analyses were used to evaluate mortality at 28, 90, and 180 days. Secondary outcomes included hospital and ICU length of stay (LOS), and m

SUBMITTER: Fan ZK 

PROVIDER: S-EPMC12241261 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature