Circular RNA profiling identifies circ_0001522, circ_0001278, and circ_0001801 as predictors of unfavorable prognosis and drivers of triple-negative breast cancer hallmarks.

ABSTRACT: Breast cancer poses a significant clinical challenge due to its complex molecular landscape, underscoring the need for improved prognostic and therapeutic strategies. In this study, we explored the expression profiles and therapeutic relevance of circular RNAs (circRNAs) in a cohort of 96 breast cancer patients from Qatar representing the MENA region. Our data identified distinct expression patterns in relation to breast cancer subtypes, tumor grade, and age, with fifty circRNAs found to be associated with unfavorable relapse-free survival (RFS). The expression of sixteen of these circRNAs was validated in triple-negative breast cancer (TNBC) model using RNase R resistance assay. Among these, the expression of circ_0001522, circ_0001278, and circ_0001801 was validated using divergent prime

SUBMITTER: Awata D 

PROVIDER: S-EPMC12241340 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature