The effects of socioeconomic position on endogenous pain modulation: A quasi-experimental approach.

ABSTRACT: Socioeconomic Position (SEP) is a multidimensional construct encompassing education, income, occupation, and neighborhood distress, influencing chronic pain severity, interference, and duration. However, its impact on placebo analgesia, where reduced pain perception occurs due to treatment belief, remains understudied. Using a quasi-experimental approach, we investigated SEP's influence on placebo analgesia in 401 participants with temporomandibular disorder (TMD) and 400 pain-free individuals. Using latent class analysis, we grouped participants into two SEP groups based on self-reported education, income, occupation, and neighborhood distress indices, including the area deprivation and distressed community indexes. Ancestry Informative Markers (AIMs) and self-reported race were included

SUBMITTER: Raghuraman N 

PROVIDER: S-EPMC12241465 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature