Factors related to blood-based biomarkers for neurodegenerative diseases and their intergenerational associations in the Young Finns Study: a cohort study.

ABSTRACT:

Background

Blood-based biomarkers (BBM) of neurodegenerative diseases are emerging as cost-effective tools in the differential diagnostics of Alzheimer's disease and other dementias. Scarce data exist about factors explaining BBM variation in population-based cohorts, and their intergenerational associations are unknown. This study aimed to characterise BBM distributions among a population-based cohort, investigate the association of a wide array of factors with BBM both in midlife and old age, and investigate intergenerational associations of BBM.

Methods

We measured BBM detecting amyloid β and tau pathologies, including amyloid β42, amyloid β40, and phosphorylated Tau (pTau)-217, as well as glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) in the m

SUBMITTER: Heiskanen MA 

PROVIDER: S-EPMC12242518 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature