Adherence to life's essential 8 is associated with delayed white matter aging.

ABSTRACT:

Background

The American Heart Association introduced Life's Essential 8 (LE8) to promote cardiovascular health and longevity. However, its impact on brain ageing and interactions with genetic risk factors of dementia, such as APOE4, remains unclear. This study investigates the relationship between LE8 and white matter brain ageing and evaluates the moderating effects of the APOE4 allele.

Methods

This cross-sectional study utilized data from the UK Biobank, including genetic, neuroimaging, and health-related data from touchscreen questionnaires, physical examinations, and biological samples. Participants were non-pregnant whites with LE8 variables, diffusion tensor imaging (DTI) data, and APOE4 genetic information available, excluding those with extreme white matter hyperinte

SUBMITTER: Feng L 

PROVIDER: S-EPMC12242590 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature