An Eco-Friendly Method for Saturated Hydrocarbon Chlorination: Exploring the Potential of First-Row Transition Metal Ions.

ABSTRACT: The functionalization of saturated hydrocarbons in a controlled, efficient, and selective manner represents a significant challenge in modern chemistry due to the low reactivity of their C-H bonds. This study introduces a new chlorination method using trichloroisocyanuric acid (TCCA) as the halogenating agent and first-row transition metal salts as catalysts. The investigation utilized four different substrates (cyclohexane, n-hexane, cycloheptane, and norbornane) along with eight transition metal ions (V-(IV), Cr-(III), Mn-(II), Fe-(II), Ni-(II), Co-(II), Cu-(II), and Zn-(II)) as potential catalysts and further Li⁺. The reactions were conducted with a substrate:TCCA:catalyst ratio of 1000:333:1 at 25, 50, and 75 °C for 24 h. The highest yields were obtained with Cu-(ClO<

SUBMITTER: Neves ES 

PROVIDER: S-EPMC12242647 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature