Controlled Release of Perillyl Alcohol via pH-Responsive Chitosan-Polypyrrole Nanocarriers.

ABSTRACT: This work focused on developing CS/PPy, a pH-responsive controlled-release nanocarrier composed of natural polymer, the chitosan (CS), and synthetic polymer, the polypyrrole (PPy). The goal was to evaluate its potential application in controlled release studies of perillyl alcohol (POH). To enhance its properties, CS/PPy was cross-linked with glutaraldehyde, resulting in a new material, CS/PPy/GA. CS/PPy and CS/PPy/GA demonstrated high encapsulation efficiency for POH. The release of POH was investigated at pH 4.5, 6.0, and 7.4. The POH release rate exhibited pH-dependent behavior, with a significantly higher release observed in acidic media (pH 4.5) compared to neutral/basic media (pH 7.4). This suggests the potential for controlled release of POH in response to specific physiological env

SUBMITTER: Borges MMC 

PROVIDER: S-EPMC12242680 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature