Human LY9 governs CD4⁺ T cell IFN-γ immunity to <i>Mycobacterium tuberculosis</i>.

ABSTRACT: CD4⁺ T cells are indispensable for optimal immunity to Mycobacterium tuberculosis (M.tb), a pathogen that triggers tuberculosis (TB) in humans. M.tb-specific human CD4⁺ T cells are known to polarize toward an interferon-γ (IFN-γ)-producing, CCR4^-CCR6⁺CXCR3⁺T-bet⁺RORγT⁺ T helper 1* cell (T_H1*cell) memory phenotype. We report that autosomal recessive deficiency of the human lymphocytic surface receptor LY9 (SLAMF3 and CD229), which is found in less than 10^-5 individuals in the general population, underlies TB in three unrelated patients due to selective impairment in IFN-γ production by T_H1* cells. T_H1* cells express higher levels of LY9 than other CD4

SUBMITTER: Ogishi M 

PROVIDER: S-EPMC12242830 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature