Dimerization of pillar[5]arene: length-adaptive encapsulation of long-chain guests.

ABSTRACT: Encapsulation of long-chain molecules is challenging because host molecules must capture entire guest structures through interactions at multiple points. Cavitand and capsule molecules bind long-chain guests within their cavities, where long-chain guests adopt compressed conformations, to maximize interaction with the walls of the receptors. However, pillar[5]arene exhibits selective binding toward linear guest molecules in an extended chain conformation. It interacts more strongly with shorter guest molecules than with longer ones, as the shorter guests better match the length of the pillar-shaped cavity. Consequently, pillar[5]arene binds poorly to long-chain guest molecules that exceed its length. Herein, we synthesized pillar[5]arene dimers linked by phenyl and biphenyl linkers. Due to

SUBMITTER: Ohtani S 

PROVIDER: S-EPMC12242831 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature