Bicyclic anionic receptors for carboxylates in water.

ABSTRACT: The selective recognition of carboxylates in water, the biological solvent, could have various applications in biology and medicine. Of particular interest is the design of antibiotics which mimic the glycopeptides such as vancomycin through binding C-terminal peptide units involved in bacterial cell wall synthesis. Here we report a general approach to carboxylate receptors with structures capable of encapsulating and interacting with all parts of their substrates. The synthesis involves elaboration of a diamino bridge unit into a bicyclic system incorporating a tetralactam anion binding site. Water-solubility can be achieved in a final step which introduces two dendrimeric nonacarboxylate units via Cu(i)-catalysed azide-alkyne cycloaddition. Three examples have been prepared and fo

SUBMITTER: Ren X 

PROVIDER: S-EPMC12243157 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature