An SNP-dependent cancer-testis antigenic epitope serves as a promising immunotherapeutic target for cancer.

ABSTRACT: T cells recognize peptides presented by human leukocyte antigen molecules on the cell surface, enabling the immune surveillance of pathological conditions such as cancer. Cancer-testis (CT) antigens are promising targets for cancer immunotherapy because of their restricted expression in normal tissues. In this study, we performed antigen screening of T cell receptors isolated from tumor-infiltrating lymphocytes (TILs) in acral melanoma, using cDNA expression cloning and identified a novel CT antigenic epitope encoded by MAGE-A6 with a single nucleotide polymorphism (SNP). This SNP conferred immunogenicity to the epitope, eliciting a robust immune response against tumor cells. While antigen identification has increasingly relied on reverse immunology approaches using reference sequen

SUBMITTER: Murata K 

PROVIDER: S-EPMC12243901 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature