Neural underpinnings of memory encoding and retrieval: Validation of a novel ecologically valid fMRI paradigm.

ABSTRACT: Cognitive impairment is prevalent in affective disorders. Currently, there is a lack of effective treatment options, which is partly due to limited insight into their neural underpinnings and poor transfer to everyday life. Integrating neuroimaging measures in cognition trials to identify neurocircuitry biomarkers is crucial for treatment development. We pooled baseline data from two clinical trials to validate a novel functional magnetic resonance imaging (fMRI) paradigm simulating real-life verbal learning and memory tasks. Healthy participants with no psychiatric history (n = 34) underwent fMRI and an ecologically valid virtual reality-based verbal memory task. During fMRI, they performed an ecologically valid paradigm involving encoding and recognition of a grocery shopping list. Whole

SUBMITTER: Thommesen KK 

PROVIDER: S-EPMC12243977 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature