Diverse Subpopulations of Reactive Astrocytes Following Chronic Toxoplasma Infection.

ABSTRACT: Astrocytes provide physical and metabolic support for neurons, regulate the blood-brain barrier, and react to injury, infection, and disease. When astrocytes become reactive, maintenance of the inflammatory state and its functional implications throughout chronic neuroinflammation are all poorly understood. Several models of acute inflammation have revealed astrocyte subpopulations that go beyond a two-activation state model, instead encompassing distinct functional subsets. However, how reactive astrocyte (RA) subsets evolve over time during chronic inflammatory disease or infection has been difficult to address. Here we use a prolific human pathogen, Toxoplasma gondii, that causes lifelong infection in the brain alongside a Lcn2CreERT2 reporter mouse line to examine reactive astrocyte su

SUBMITTER: Figueroa ZA 

PROVIDER: S-EPMC12244103 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature