Noradrenergic gene variation shaping vulnerability and resilience by affecting mental health-related characteristics: A systematic review.

ABSTRACT: Mental health problems are highly prevalent worldwide. Stress can precipitate both the onset and recurrence of mental health problems. While many individuals are exposed to similar stressors, there is a large heterogeneity in sensitivity to stress and the extent to which someone subsequently develops mental health issues. A key factor that contributes to an individual's capacity to cope with adversity, referred to as resilience, is genetic variation. Here, we systematically reviewed the effects of genetic variation in the genes encoding the norepinephrine (NE) transporter and receptors on resilience- and mental health-related features in a transdiagnostic approach (i.e., without restrictions regarding factors such as diagnosis or age). Our search yielded 49 studies for inclusion. The curre

SUBMITTER: van Hooijdonk CFM 

PROVIDER: S-EPMC12244201 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature