XML Attenuates Ox-LDL-Induced Endothelial Progenitor Cell Senescence via Gria2 and cAMP Pathways.

ABSTRACT: In-stent restenosis (ISR) following percutaneous coronary intervention (PCI) is a critical clinical issue, often arising from endothelial injury and impaired repair mechanisms. Endothelial progenitor cells (EPCs), derived from bone marrow, play a key role in vascular health, but their function diminishes with aging and exposure to oxidised low-density lipoprotein (ox-LDL). This study investigates the potential of Xin-Mai-Long (XML), a traditional Chinese medicine used for chronic congestive heart failure, to delay EPC senescence and dysfunction induced by ox-LDL. Our findings demonstrate that XML administration significantly attenuates ox-LDL-induced EPC senescence and dysfunction. RNA sequencing identified Gria2 as a crucial gene downregulated by ox-LDL and restored by XML. Overexpression

SUBMITTER: Wu J 

PROVIDER: S-EPMC12244391 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature