Anticoagulant therapy and altered tissue factor expression protect against experimental placental and cerebral malaria.

ABSTRACT: Severe malaria remains a major public health concern in regions of moderate to high Plasmodium falciparum transmission. Women and young children are especially vulnerable to two clinical manifestations of severe P. falciparum malaria, known as placental malaria (PM) and cerebral malaria (CM). Both PM and CM have been characterized as procoagulant states; however, the role of coagulation in galvanizing poor health outcomes is incompletely understood. Moreover, the contribution of tissue factor (TF), the primary driver of the extrinsic pathway of coagulation, to the pathogenesis of PM and CM has not been fully explored. This work utilizes experimental murine models of PM (EPM) and CM (ECM) to explore the impact of anticoagulant treatment and tissue-specific or global reduction in TF expressi

SUBMITTER: Andrew AK 

PROVIDER: S-EPMC12244638 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature