Reproducible sex differences in personalised functional network topography in youth.

ABSTRACT:

Background

A key step toward understanding psychiatric disorders that disproportionately impact female mental health is delineating the emergence of sex-specific patterns of brain organisation at the critical transition from childhood to adolescence. Prior work suggests that individual differences in the spatial organisation of functional brain networks across the cortex are associated with psychopathology and differ systematically by sex.

Aims

We aimed to evaluate the impact of sex on the spatial organisation of person-specific functional brain networks.

Method

We leveraged person-specific atlases of functional brain networks, defined using non-negative matrix factorisation, in a sample of n = 6437 youths from the Adolescent Brain Cognitive Development Study.

SUBMITTER: Keller AS 

PROVIDER: S-EPMC12245598 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature