Identification and analysis of cuproptosis associated molecular clusters and immunological profiles in atopic dermatitis.

ABSTRACT:

Background

Atopic dermatitis (AD) is a chronic skin condition marked by persistent itching and dryness. The role of cuproptosis, a novel form of programmed cell death, in AD is not yet understood.

Methods

The GSE107361 dataset was obtained from the Gene Expression Omnibus (GEO) database. Cuproptosis-related genes (CRGs) in AD were identified and analyzed, and immune landscape analysis was performed using ssGSEA. AD was clustered based on CRGs using ConsensusClusterPlus. Weighted gene co-expression network analysis (WGCNA) and differential gene expression analysis were conducted. Hub genes between AD clusters were identified, and both protein-protein interaction (PPI) and drug-gene interaction networks were developed.

Results

Three CRGs (DLD, MTF1, and GLS) were signif

SUBMITTER: Wang L 

PROVIDER: S-EPMC12245679 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature