Evaluating finger-prick blood collection for remote quantification of neurofilament light in neurological diseases.

ABSTRACT: Promising blood-based biomarkers of neuropathology have emerged with potential for therapeutic development and disease monitoring. However, these tools will require specialist tertiary services for integration into clinical management. Remote sampling for biomarker assessment could reduce burden of in-person clinical visits for such tests as well as increasing the sampling frequency and patient geographical outreach. Here, we evaluated a finger-prick blood collection approach for remote quantification of neurofilament light (NfL), a candidate blood-based biomarker evident in various neurological disorders, and other exploratory markers of neuronal injury and neuroinflammation (GFAP, tau). Matched samples from venepuncture and finger-prick were collected and processed into plasma and/or ser

SUBMITTER: Coleman A 

PROVIDER: S-EPMC12245952 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature