The link of FOXO1 and FOXO4 transcription factors to development of the lens.

ABSTRACT:

Background

The FOXOs regulate the transcription of many genes, including ones directly linked to pathways required for lens development. However, this transcription factor family has rarely been studied in the context of development, including the development of the lens. FOXO expression, regulation, and function during lens development remained unexplored.

Results

In studies of the embryonic lens, we showed that both FOXO1 and FOXO4, which share many downstream targets, are expressed in a differentiation-state-specific manner, most highly in lens epithelial and differentiating cortical fiber cells. Their expression patterns and subcellular distributions suggest both shared and distinct functions. Stabilization of FOXO cytoplasmic pools involved their binding to the chaperon

SUBMITTER: Gheyas RN 

PROVIDER: S-EPMC12246175 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature