Constitutive interaction between neutrophils and von Willebrand factor in peripheral blood.

ABSTRACT: Neutrophils are known to be able to recruit von Willebrand factor (VWF) through Neutrophil Extracellular Traps (NETs) during inflammation. However, the interaction between neutrophils with plasma VWF at physiological condition remains poorly understood. In this study, we demonstrate that peripheral neutrophils constitutively carry surface-bound VWF in a NETs-independent manner. Depletion of peripheral neutrophils in mice elevated plasma VWF levels without affecting its synthesis or secretion. A similar interaction in human blood was also observed as demonstrated from the analysis of 23 healthy human donors. Human VWF binding to neutrophils is independent of gender and age; however, individuals with non-O blood types exhibit significantly lower VWF levels on neutrophils compared to those wi

SUBMITTER: Wan Y 

PROVIDER: S-EPMC12246238 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature