Mass and stiffness sensing performance of nanomechanical resonators: viability of infectious virus detection.

ABSTRACT: We examine the performance of nanomechanical resonators for mass and stiffness sensing of nanoparticulate analytes with focus on their application for untargeted infectious virus detection. The characteristic narrow mass distributions of viruses, together with the existing correlations between their stiffness and infectivity, point out to nanomechanical sensors as a particularly suited alternative to molecular detection techniques, constrained by limited processing speed, target-specificity, and the inability to directly assess infectivity. We present a theoretical analysis of the response of flexural beam resonators to the adsorption of nanoparticulate analytes, and derive analytical expressions for the mass and stiffness sensing responsivity, resolution and signal to noise ratio as a fun

SUBMITTER: Gomez-Moreno M 

PROVIDER: S-EPMC12246276 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature