Circadian misalignment impacts cardiac autonomic modulation in adolescence.

ABSTRACT:

Study objectives

Although heart rate variability (HRV), a marker of cardiac autonomic modulation (CAM), is known to predict cardiovascular morbidity, the circadian timing of sleep is also involved in autonomic modulation. We examined whether circadian misalignment is associated with blunted HRV in adolescents as a function of entrainment to school or on-breaks.

Methods

We evaluated 360 subjects from the Penn State Child Cohort (median 16 years) who had at least 3-night at-home actigraphy (ACT), in-lab 9-h polysomnography, and 24-h Holter-monitoring HRV data. ACT-measured metrics of circadian misalignment included sleep midpoint (SM), sleep irregularity (SI), and social jetlag (SJL). Five 24-h, daytime, and nighttime frequency- and time-domain HRV indices were the primary out

SUBMITTER: Morales-Ghinaglia N 

PROVIDER: S-EPMC12246378 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature