PLIN2 promotes colorectal cancer progression through CD36-mediated epithelial-mesenchymal transition.

ABSTRACT: Colorectal cancer (CRC) is one of the most common malignant tumors with high incidence and mortality. The challenge remains to construct reliable prognostic prediction models and to further elucidate the key molecular mechanisms of tumor progression. To address this, we performed WGCNA based on 120 immune cell expression profiles from GEO sources to obtain a collection of monocytes/macrophages-related genes. The prognostic model was constructed by univariate survival analysis and LASSO regression analysis. Then, the prognostic model was validated by Multivariate Cox regression, Kaplan-Meier survival analysis and ROC analysis. In this prognostic model, we identified that PLIN2 has a potential value for CRC prognosis. PLIN2 expression in monocytes/macrophages was verified by scRNA-seq datase

SUBMITTER: Yang F 

PROVIDER: S-EPMC12246428 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature