Perinatal depressive and anxiety symptoms are associated with gut microbiota in pregnant women with overweight and obesity.

ABSTRACT: The associations of gut microbiota with depressive and anxiety symptoms have been investigated mainly in non-pregnant humans, and currently there is a significant gap in research on pregnant women, especially those who are living with overweight and thus at a higher risk for experiencing perinatal mental health problems. In this study, we used shotgun metagenomic sequencing to analyze the gut microbiota of pregnant women with overweight and obesity, both in early and late pregnancy. We compared gut microbial diversity, composition, and function across groups with different trajectories of depressive (n=419) and anxiety (n=408) symptoms. Depressive symptoms were assessed using the Edinburgh Postnatal Depression Scale (EPDS), and anxiety symptoms were evaluated with the Symptom Checklist 90

SUBMITTER: Hieta J 

PROVIDER: S-EPMC12246855 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature