The SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation.

ABSTRACT: Regulation of gene expression underlies cell differentiation and organogenesis. Both transcription factors and chromatin modifiers are crucial for this process. To study the role of the ATP-dependent SWI/SNF chromatin-remodeling complex in cell differentiation, we inactivated the gene encoding the core complex subunit SNF5/INI1 in the developing liver. Hepatic SNF5 deletion caused neonatal death due to severe hypoglycemia; mutant animals fail to store glycogen and have impaired energetic metabolism. The formation of a hepatic epithelium is also affected in SNF5-deficient livers. Transcriptome analyses showed that SNF5 inactivation is accompanied by defective transcriptional activation of 70% of the genes that are normally upregulated during liver development. These include genes involved i

SUBMITTER: Gresh L 

PROVIDER: S-EPMC1224692 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature