Clonorchis sinensis infection remodels chromatin accessibility in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a major global health concern, accounting for a significant proportion of liver cancer cases and related deaths. Clonorchis sinensis (C. sinensis) infection, a recognized carcinogen, has been implicated in the progression of liver diseases, including HCC. However, the precise epigenetic mechanisms underlying C. sinensis-associated HCC remain to be elucidated.

Methods

To investigate the role of chromatin accessibility in C. sinensis-related HCC progression, we performed an assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) and RNA sequencing (RNA-seq) analyses of C. sinensis-infected (C. sinensis⁺) and non-C. sinensis-infected (C. sinensis^-) HCC tumors. Integrated analyses we

SUBMITTER: Yang W 

PROVIDER: S-EPMC12247385 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature