Alpha-180 spin-echo-based line-scanning method for high-resolution laminar-specific fMRI in animals.

ABSTRACT: Laminar-specific functional magnetic resonance imaging (fMRI) has been widelyused to study circuit-specific neuronal activity by mapping spatiotemporal fMRIresponse patterns across cortical layers. Hemodynamic responses reflect indirectneuronal activity given the limitation of spatial and temporal resolution.Previously, a gradient-echo-based line-scanning fMRI (GELINE) method wasproposed with high temporal (50 ms) and spatial (50 µm) resolution tobetter characterize the fMRI onset time across cortical layers by employing twosaturation RF pulses. However, the imperfect RF saturation performance led topoor boundary definition of the reduced region of interest (ROI) and aliasingproblems outside of the ROI. Here, we propose an α (alpha)-180spin-echo-based line-scanning fMRI (SELINE) method in

SUBMITTER: Choi S 

PROVIDER: S-EPMC12247619 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature