Parental age selection in <i>C. elegans</i> influences progeny stress resistance capacity.

ABSTRACT: With parental age rising around the globe, an increased understanding of the impact on health and longevity is needed. Here, we report how the continuous selection of the last progeny during the Caenorhabditis elegans reproductive span results in a diminishment of multiple age-related health measures. After more than fifty generations of late selection, progeny displayed diminished resistance to acute oxidative stress, disrupted partitioning of stored lipids, reduced movement capacity, and an overall shortening of lifespan. In contrast, starvation resistance was improved and late selection had negligible effects on developmental timing and total reproductive output that suggests a reduction in lifespan health to preserve reproductive capacity. The phenotypes of late selection are re

SUBMITTER: Van Camp BT 

PROVIDER: S-EPMC12247647 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature