Interplay between MIG-6/papilin and TGF-β signaling promotes extracellular matrix remodeling and modulates the maintenance of neuronal architecture.

ABSTRACT: Neuronal architecture laid out during embryogenesis persists lifelong, ensuring normal nervous system function. However, the mechanisms underlying the long-term maintenance of neuronal organization remain largely unknown. We previously uncovered that the conserved extracellular matrix protein MIG-6/papilin impacts collagen IV remodeling and neuronal maintenance, such that disruption of MIG-6/papilin leads to a collagen IV fibrotic state and altered tissue biomechanics, thereby stabilizing neuronal architecture. Here, we combine incisive molecular genetics and in vivo quantitative imaging to determine how this mig-6-dependent fibrotic phenotype is modulated, by investigating the implication of the TGF-β pathway, which is well known to regulate fibrosis in mammals. Our findings

SUBMITTER: Nadour M 

PROVIDER: S-EPMC12247666 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature