The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit.

ABSTRACT: A coordinated response to stress is crucial for promoting the short- and long-term health of an organism. The perception of stress, frequently through the nervous system, can lead to physiological changes that are fundamental to maintaining homeostasis. Activating the response to low oxygen, or hypoxia, extends healthspan and lifespan in C. elegans. However, despite some positive impacts, negative effects of the hypoxic response in specific tissues prevent translation of their benefits in mammals. Thus, it is imperative to identify which components of this response promote longevity. Here, we interrogate the cell-nonautonomous hypoxic response signaling pathway. We find that HIF-1-mediated signaling in ADF serotonergic neurons is both necessary and sufficient for lifespan extension.

SUBMITTER: Kitto ES 

PROVIDER: S-EPMC12247763 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature