Discovery of giant viruses as past and present infections of zoosporic fungi.

ABSTRACT: Giant viruses of the phylum Nucleocytoviricota have emerged as particularly notable due to their increasingly recognized impacts on eukaryotic genome evolution. Their origins are hypothesized to predate or coincide with the diversification of eukaryotes, and they have been detected in hosts that span the eukaryotic tree of life. But surprisingly, such viruses have not been definitively found in Kingdom Fungi, though genomic and metagenomic work suggests a putative association. Here we report both "viral fossils" and active infection by giant viruses in fungi, particularly in the zoosporic phyla Blastocladiomycota and Chytridiomycota. The recovered viral genomes span up to 350 kb, encode over 300 genes, and form a monophyletic family-level clade within the Nucleocytoviricota r

SUBMITTER: Myers JM 

PROVIDER: S-EPMC12247965 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature