Excess prenatal folic acid supplementation alters cortical gene expression networks and electrophysiology.

ABSTRACT: Folate is crucial for various biological processes, with deficiencies during pregnancy being linked to increased risk for neural tube defects and neurodevelopmental disorders. As a proactive measure, folic acid fortification in foods has been mandated in many countries, in addition to dietary supplementation recommendations during pregnancy. However, the risks of excess prenatal folic acid supply have yet to be fully understood. To better appreciate in utero molecular changes in mouse brain exposed to 5-fold folic acid excess over normal supplementation, we investigated the transcriptome and methylome for alterations in gene networks. RNA-seq analysis of cerebral cortex collected at birth, revealed significant expression differences in 646 genes with major roles in protein translati

SUBMITTER: Haghani V 

PROVIDER: S-EPMC12248018 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature