Oligomerization of the <i>Clostridioides difficile</i> Transferase B Component Proceeds through a Stepwise Mechanism.

ABSTRACT: Clostridioides difficile is a gram-positive, pathogenic bacterium and is currently the leading cause of hospital-acquired, infectious diarrhea in the United States. During infection, C. difficile produces and secretes up to three toxins called Toxin A, Toxin B, and the C. difficile transferase (CDT). While Toxin A and Toxin B are thought to drive the pathology associated with the disease, strains that produce CDT have been linked to increased disease severity, higher rates of infection recurrence, and increased incidence of mortality. A basic understanding of how CDT intoxicates host cells has emerged over the past two decades and includes a framework that relies on the oligomerization of the components that comprise CDT to promote cellular intoxication. Although sever

SUBMITTER: Mullard RM 

PROVIDER: S-EPMC12248058 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature