BRAF^V600E-Driven Lung Tumorigenesis Requires Ligand-Mediated Activation of ERBB Receptor Signaling.

ABSTRACT: Secretion of ligands of the human epidermal growth factor (EGFR) family of receptors or erythroblastic leukemia viral oncogene family (ERBB1-4) is a feature common to many cancer cells. However, our understanding of the role of autocrine ligands in the aberrant behavior of cancer remains incomplete. Here we demonstrate that, in numerous preclinical models of lung tumorigenesis, BRAF^V600E signaling promotes expression of ligands including HB-EGF, TGFα, Epi- and Amphiregulin. Moreover, using both genetic or pharmacological approaches, we demonstrate that ligand-mediated activation of EGFR signaling in the tumor cell is required to sustain both early-stage BRAF^V600E-driven lung tumorigenesis and supports late-stage BRAF^V600E-driven

SUBMITTER: Dacheux MA 

PROVIDER: S-EPMC12248061 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature