Harmonized Protocol for Subfield Segmentation in the Hippocampal Body on High-Resolution <i>in vivo</i> MRI from the Hippocampal Subfields Group (HSG).

ABSTRACT: Hippocampal subfields differentially develop and age, and they vary in vulnerability to neurodegenerative diseases. Innovation in high-resolution imaging has accelerated clinical research on human hippocampal subfields, but substantial differences in segmentation protocols impede comparisons of results across laboratories. The Hippocampal Subfields Group (HSG) is an international organization seeking to address this issue by developing a histologically-valid, reliable, and freely available segmentation protocol for high-resolution T₂-weighted 3 tesla MRI (http://www.hippocampalsubfields.com). Here, we report the first portion of the protocol focused on subfields in the hippocampal body; protocols for the head and tail are in development. The body protocol includes definitions of

SUBMITTER: Daugherty AM 

PROVIDER: S-EPMC12248105 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature