Theory of interaction between untuned modulatory inputs and tuned sensory inputs.

ABSTRACT: How does the brain integrate sensory inputs with non-feature-tuned signals, such as those arising from behavioral state changes or neuromodulation? Here, we show that the dynamics of disordered E/I networks with structured, feature-dependent connectivity can be well characterized by an effective model describing interactions between the responses of cells who prefer the current sensory stimulus ("matched" cells) and the responses of cells firing at the baseline. This effective network exhibits strong feedback from the baseline onto the matched responses but weak reverse projections. Thus, an untuned stimulus not only directly drives matched cells, but also indirectly drives them via modulation of the baseline. We demonstrate through a linear response analysis that the baseline effect on th

SUBMITTER: Nguyen T 

PROVIDER: S-EPMC12248107 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature