Neonatal infection with <i>Helicobacter pylori</i> affects stomach and colon microbiome composition and gene expression in mice.

ABSTRACT: The stomach bacterium Helicobacter pylori is estimated to infect half of the world's population, and the health implications are affected by the age at infection. Neonatal H. pylori infection of mice is a relevant model to investigate metabolic and immunological effects. We performed an explorative study at the dynamic first month of life, to compare the composition of the gastrointestinal tract microbiome and stomach gene expression of mice neonatally infected with H. pylori with that of uninfected mice. We found that H. pylori was present only in the stomach, and that H. pylori loads increase with age from one week after infection and onwards, especially after weaning. Stomach and colon microbiome composition was strikingly similar between sites at the

SUBMITTER: Graversen KB 

PROVIDER: S-EPMC12248114 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature