Astrocyte-derived PTPRZ1 regulates astrocyte morphology and excitatory synaptogenesis.

ABSTRACT: Protein tyrosine phosphatase receptor type Z1 (PTPRZ1) is one of the most abundantly expressed and enriched proteins in astrocytes during development, yet its function in astrocytes is unknown. Using an astrocyte-neuron co-culture system, we found that knockdown of Ptprz1 in astrocytes significantly impaired astrocyte branching morphogenesis. To investigate the function of PTPRZ1 in astrocytes during brain development, we generated a Ptprz1 conditional knockout mouse and deleted Ptprz1 from astrocytes postnatally, after the bulk of astrogenesis is complete. At postnatal day 21, we found defects in astrocyte morphology and a reduction in excitatory synapse number across multiple layers of the visual cortex, suggesting important functions for astrocytic PTPRZ1 in both as

SUBMITTER: Eaker AR 

PROVIDER: S-EPMC12248130 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature