Early psychosis is characterized by white matter abnormalities in fiber structures supporting local connectivity.

ABSTRACT:

Background

While long-range white matter (WM) connectivity has been widely studied in schizophrenia-spectrum disorders (SSDs), recent evidence highlights the importance of local network disruptions. Superficial white matter (SWM), located between cortex and WM, comprises short association fibers supporting local connectivity. As SWM matures in the latter stages of development relative to deep WM structures, it may be particularly vulnerable to neurodevelopmental disruptions observed in SSDs. However, its complex fiber architecture and proximity to the cortex pose challenges for conventional diffusion tensor imaging.

Methods

To overcome these limitations, we applied an advanced diffusion MRI approach to assess fiber density (FD) in the SWM of 78 individuals with early psychos

SUBMITTER: Saito Y 

PROVIDER: S-EPMC12248151 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature