Single pulse electrical stimulation in white matter modulates iEEG visual responses in human early visual cortex.

ABSTRACT: Electrical stimulation is increasingly used to modulate brain networks for clinical purposes. The basic unit of neurostimulation, a single electrical pulse, can travel through white matter to influence connected neuronal populations. However, the mechanisms by which it influences connected populations is not well understood: stimulation may excite, inhibit, or add noise to neuronal population activity. In this study, we investigated how single pulses modulate the neuronal processing of images in a well-controlled visual paradigm. In two human subjects implanted with iEEG electrodes for clinical purposes, single pulses were delivered to electrodes in white matter tracts connected to measurement electrodes in visual cortex. Images appeared on-screen at 0, 100, or 200 ms after each pulse. Usi

SUBMITTER: Huang H 

PROVIDER: S-EPMC12248153 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature