The relationship between cognitive abilities and mental health as represented by cognitive abilities at the neural and genetic levels of analysis.

ABSTRACT: Cognitive abilities are often linked to mental health across various disorders, a pattern observed even in childhood. However, the extent to which this relationship is represented by different neurobiological units of analysis, such as multimodal neuroimaging and polygenic scores (PGS), remains unclear. Using large-scale data from the Adolescent Brain Cognitive Development (ABCD) Study, we first quantified the relationship between cognitive abilities and mental health by applying multivariate models to predict cognitive abilities from mental health in children aged 9-10, finding an out-of-sample r =.36. We then applied similar multivariate models to predict cognitive abilities from multimodal neuroimaging, polygenic scores (PGS) and environmental factors. Multimodal neuroimaging was

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12248171 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature